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Radiation headed oxidative stress produces lipid peroxidation, a condition in which ROSs bind to polyunsaturated fatty acids in membrane [16]

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Moving to anaplastic TC, an in vitro study demonstrated that in a panel of six anaplastic thyroid cancer (ATC) cell lines, the treatment with ciglitazone reduced anchorage-dependent and -independent growth and migration, and increased the apoptosis rate of TC cells ( in vitro study showed that ciglitazone induced apoptosis of TC cells by affecting the cytochrome-c caspase 3 and PTEN-Akt pathways, in addition the necrosis was obtained by affecting the PARP pathway ( Lobeglitazone Lobeglitazone activates PPAR- and promotes the binding of insulin at fat cells, reduces blood sugar levels, lowers hemoglobin A1C (HbA1C) levels, and improves lipid and liver profiles (National Center for Biotechnology Information, 2023i)

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