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81770327, 81100173) and Capital Health Research and Development of Special Fund (M2022038, China)

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DMP IGF-I KO mice, in which the IGF-I gene is deleted in osteocytes using DMP-1 promoter-driven Cre, do not have altered serum IGF-I, calcium, or phophorus levels, but do show decreased serum levels of the bone formation maker procollagen type I N-terminal propeptide (PINP) and the bone resorption marker, c-telopeptide (CTx)