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Reduced hepatic steatosis in fasted c av1 / mice was suggested to be secondary to compromised metabolic function in the adipose tissue, resulting in reduced hepatic DNL (and possibly increased FAO) [29]

Healthy aging requires a balance between energy production, cellular repair, and protection from damage

The authors suggest that the negative effect of metformin on exercise results from metformin lowering ROS levels, thus reducing the effects of ROS to activate AMPK