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Moreover, we believe that recent advances in understanding the complexity and uniqueness of this distinct cell death might question the status of erythrocytes as entities between life and death

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High-quality human clinical trials are lacking, and optimal dosing, long-term safety, and efficacy have not been established, meaning its use for IBS and Crohns should be considered investigational rather than a standard therapeutic option

A Phase I human safety study was completed but never published, and regulatory concerns about safety, purity, and administration routes have complicated further clinical research

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