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its blockade increases serotonin release Promotes neurogenesis : TREK-1 knockout mice show increased hippocampal neurogenesis, and PE-22-28 recapitulates this effect pharmacologically within 4 days of treatment Induces synaptogenesis : TREK-1 blockade promotes dendritic growth and synaptic connection formation PE-22-28 inhibits TREK-1 with an IC50 of 0.12 nM, making it approximately 300-500 times more potent than spadin

The Glow Up patch changes all of that

Rapid weight loss increases gallbladder disease risk regardless of method used, and early intervention prevents complications

In practice: Topical GHK-Cu (1%) = ~25 mM total copper equivalents

These supplements work in indirect ways by stimulating different systems and can contribute to increased libido, fertility, and testosterone and estrogen levels