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If they are going to be used they should be made according to a USP monograph or be a component of an approved drug, if no monograph exists it must be on the 503A Bulk List, and it must be manufactured in an FDA registered facility with a proper certificate of analysis

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Synthetic cathinone (SC), the second most common new psychoactive substance, is a -ketone analog resembling amphetamine and is often called natural amphetamine due to its similar chemical structure and effects 43,44

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