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Cell 2008;135:3915

In the current study, the win-kindling protocol involved PTZ injections with a free-injection time period between the initial and final injections to allow a set of neural changes that increase the susceptibility of the brain to seizures, as stated by Davoudi et al

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Potential for stronger effect: Because the bioavailability (the fraction of the administered dose that reaches circulation) can be higher via injection, the impact on sleep architecture (e.g., slow-wave sleep increases) may be more pronounced

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