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Dietary polyphenols as modulators of brain functions: Biological actions and molecular mechanisms underpinning their beneficial effects

During post marketing surveillance, male infertility and/or poor seminal quality following treatment discontinuation have been reported

In healthy people, postprandial GIP levels are approximately 4-fold higher than GLP-1 levels.55 The predicted quantity of GIPR occupied by tirzepatide is also more than that of GLP-1R (6.3-fold at 5mg, 4.6-fold at 10mg and 4.1-fold at 15mg).56 This may be the secret of the extraordinary efficacy of tirzepatide, but it is still possible that the best ratio of GLP-1 and GIP activity in a dual agonist has not been discovered

They believe it's crucial for long-term success

This keeps your digestion moving smoothly, prevents constipation, and helps your kidneys process metabolic byproducts