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The lessons learned from astrocyte-targeted strategies provide a natural transition to examining microglia, whose dual role as immune defenders and potential drivers of pathology makes them equally compelling therapeutic targets (Figure 5)
Nature 455, 894902
Hypothalamic dysfunction from paternally imprinted gene deletions is the main pathogenesis of PWS and is characterized by short stature, infantile hypotonia, hypothalamic hypogonadism, excessive appetite, and progressive obesity [1,2]
It lowers blood sugar levels, improves insulin sensitivity, and may support weight loss