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These nonseroconverters include people on B-cell-depleting therapy or people with inborn errors of immunity, as these individuals are typically more susceptible to prolonged infection and higher rates of progression to severe disease [36, 37]

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Key maternal effect genes show coordinated downregulation during early cleavage stages, with the kinetics of maternal transcript clearance correlating strongly with embryo developmental potential [386]

[43:01] When you zoom out and ask, well, what creates the immune susceptibility for all these weird things to happen