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Endpoint Assessment: Lipolysis: Glycerol and fatty acid release Gene expression: Lipid metabolism enzymes Body composition: Fat and lean mass Metabolic parameters: Without glucose/IGF-1 changes Mechanism Investigation: Key research questions: What is the molecular target of AOD9604

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Our nanoBRET findings demonstrate that DA activation of the 2A -adrenergic receptor primarily results in recruitment of G i1 to the receptor with negligible -arrestin2 recruitment while NE treatment causes robust recruitment of both the G protein and -arrestin2