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The source of this increase requires more detailed investigation

L'essai de Richie et al

Similarly, SYNCHRONIZE-CVOT (survodutide), a glucagon/GLP-1 receptor co-agonist, is being evaluated in a large-scale randomized controlled trial to assess its cardiovascular safety and efficacy in people with obesity (93)

Gandasi NR, Yin P, Omar-Hmeadi M, Ottosson Laakso E, Vikman P, Barg S (2018) Glucose-dependent granule docking limits insulin secretion and is decreased in human type 2 diabetes

Many people call this phenomenon semaglutide face or, more commonly, Ozempic face. (You may also hear the terms Ozempic butt or Ozempic arms on social media, referring to similar weight loss in those areas.) In other words, taking semaglutide may cause you to lose volume in your cheeks and around your eyes