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It is a prescription drug in most jurisdictions, approved by the FDA for acne and, in specific formulations, for the treatment of photoaging (fine wrinkling, mottled hyperpigmentation, and roughness)

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A normal TSH level excludes hyperthyroidism and an elevated TSH level is generally diagnostic for hypothyroidism

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Its well-established mechanism of action continues to make Melanotan II a valuable research compound for exploring the biological pathways that regulate pigmentation and melanocortin signaling