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It is unknown whether the divergent effects on heart rate achieved by different GLP-1 analogs may contribute to cardiovascular outcomes

About 30% to 60% of the time, people develop a life-threatening condition called diabetic ketoacidosis (DKA)

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Duration matters significantly: short-term prednisone courses (1014 days) create minimal metabolic conflict, while chronic use (months or years) substantially undermines semaglutide's effectiveness

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