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Semaglutide is generally not used during pregnancy or breastfeeding, in people with the thyroid or MEN 2 history above, with a history of pancreatitis, or with certain other conditions

Clinical studies have shown its benefits in reducing the occurrence of major cardiovascular events in patients with or without type 2 diabetes

These medications are appropriate when their benefits outweigh their risks, says Charlie Seltzer, MD , a board-certified obesity medicine doctor in Philadelphia

Oral semaglutide offers a mechanism that supports appetite regulation and metabolic balance, making it suitable for patients who require more than lifestyle modification alone to achieve progress

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