doi:10.1159/000053183 Heffernan M, Summers RJ, Thorburn A, et al
Today, there are three injectable GLP-1s available in the United States
Patients on 2.4 mg (Wegovy dose) or 2 mg (common compounded dose) have less safety margin
When to contact your clinician promptly Severe or persistent abdominal pain (especially to the back), repeated vomiting, or signs of dehydration Yellowing of the skin/eyes, clay-colored stools, or fever with abdominal pain Vision changes or symptoms of low blood sugar if you also use insulin or certain diabetes pills Signs of allergy: trouble breathing, swelling, hives Bottom line Semaglutide works best when you pair it with protein at every meal, plants for fiber, steady fluids, and simple movement
The dual GIP/GLP-1 mechanism of tirzepatide may produce a different GI side-effect profile in some patients