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Although these studies do not specifically differentiate between neuronal and astrocytic contributions, it is possible that the modulation of astrocytic A 1 and A 2A receptors may have an impact on the onset and progression of ALS, given the well-established importance of astrocytes in the disease [435]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 149.Zhu B.Q., Simonis U., Cecchini G., Zhou H.Z., Li L., Teerlink J.R., Karliner J.S