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Interstrand cross-link formation involving reaction of a Mispaired Cytosine Residue with an abasic site in duplex DNA

In the ovary, DCI is responsible for an excess production of insulin-dependent testosterone, whereas MI enhances the action of FSH, via anti-Mllerian hormone (AMH)

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However, in T2DM patients, incretin accounts for just 20% of total insulin secretion due to decreased incretin secretion and dysfunctional receptor or postreceptor signaling, resulting in a decreased postprandial insulin and C-peptide secretion response, which contributes to hyperglycemia [3]

These medicines have not been approved for use in people with Type 1 diabetes, although researchers are currently studying the safety and effectiveness for people with Type 1