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DOI:10.2147/DDDT.S82030 B.ebei,V.Nikoli,PSikiri,S.Seiwerth,Osteogenic effect of a gastric pentadecapeptide, BPC-157, on the healing of segmental bone defect in rabbits: a comparison with bone marrow and autologous cortical bone implantation
High doses, repeated administration, vulnerable populations (pregnant animals), and sensitive tissues (gastrointestinal tract, reproductive organs) have all been evaluated
Environmental factors are also likely to play a role in the aetiology of RA, with smoking a well-established risk factor elevating susceptibility to disease development
loss of elasticity and firmness
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