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LC is a substrate for gut microbiota, and its metabolism affects both microbial composition and human metabolic pathways

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The GLP-1R is rapidly internalized when activated by its cognate agonist 9 , but the effect of internalization and subsequent post-endocytic trafficking on overall GLP-1 responses is not clear

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They point out the gap in current research and the necessity for clinical trials that specifically address the safety and efficacy of semaglutide in this population