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Studies demonstrate FOXO4-DRI achieves comparable renal function restoration to genetic clearance of senescent cells using the p16-3MR suicide gene system, confirming that therapeutic effects result specifically from senescent cell elimination rather than off-target actions

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An optimized mouse brain atlas for automated mapping and quantification of neuronal activity using iDISCO+ and light sheet fluorescence microscopy

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AlvarezJAChowdhuryRJonesDPMartinGSBrighamKLBinongoJNet al

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