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Disease-modifying antirheumatic drugs (DMARDs) like methotrexate can slow autoimmune progression when started within 6 months of symptom onset, significantly improving long-term outcomes

It also reinforces a broader lesson from precision medicine: the future may lie not in finding one solution for many diseases, but in understanding what makes each disease unique

Why the caution

FIGURE 3 5.1.1 Sun protections The key strategy for melasma management is consistent photoprotection through the application of broad-spectrum sunscreens with a notably high level of sun protection factor (SPF) of 50+ and persistent pigment darkening (PPD) of +++ or ++++) (Jansen et al., 2013)