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But mice are not humans, and the research community knew that the real test would come in larger, more complex animals

, Laux, G., Nagatsu, T., Le, W., & Riederer, C

The disruption of the HGF/c-MET signaling pathway, which has been preserved through evolution, leads to a complex array of events within cells that contribute to the development of tumors

Ras leads to the activation of different mitogen-activated protein kinase (MAPK) cascades, including extracellular-signal-regulated kinase (ERK), p38 MAPK , and c-Jun N-terminal protein kinase (JNK) (Graziani et al., 1993)

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