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Insulin resistance, a characteristic marker of type 2 diabetes is a condition in which the regulation of glucose metabolism in body tissues, such as the liver, adipose tissue, and skeletal muscle, becomes disrupted

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In the case of muscle-specific IR, mitochondrial dysfunction is characterized by metabolic abnormalities and diminished oxidative phosphorylation, decreased electron transport chain activity, and low expression levels of PGC1, a master transcriptional regulator of mitochondrial biogenesis [79]

Nonviral gene delivery refers to DNA passage through cell membranes using physical and chemical methods such as electroporation