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VHL alterations in RCC cells lead to the activation of hypoxia-inducible factors and their downstream target vascular endothelial growth factor, and to the reprogramming of multiple cell death pathways and metabolic weakness, including ferroptosis, which are associated with targeted therapy or immunotherapy

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Activated immune cells, particularly macrophages and T/B lymphocytes, profoundly influence iron homeostasis and lipid peroxidation through NF-KB, Nrf2/HO-1, and other signaling pathways

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doi: 10.1016/j.bbamcr.2016.01.023