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Extracellular matrix and visual cortical plasticity: freeing the synapse

Your clinician may suggest a nonhormonal menopausal treatment if you have a history of: stroke or blood clots (transdermal estrogen may be an option as studies do not show an increased risk with transdermal forms, like patches) some types of heart or liver problems, including a history of heart attack or unmanaged high blood pressure cancer that might be stimulated by hormones, like hormone-sensitive breast cancer Other contraindications include current pregnancy (yes, you can get pregnant while in perimenopause) and unexplained vaginal bleeding

Chronic Complication Mechanisms: Sustained hyperglycemia damages small vessels (microvascular disease) via multiple mechanisms including AGE accumulation, protein kinase C activation, and hexosamine pathway flux

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