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This can be a problem for your organs, which are now not getting enough oxygen, leading to a whole host of concerning symptoms, which include: Anemia Fatigue and weakness Depression Irritability Yellowing skin Soreness of mouth and tongue Weight loss or decreased appetite Numbness of extremities Vision problems Other neurological and psychological symptoms may include fogginess, confusion, and a shift in personality and behavior

Protective effects of goldenseal (Hydrastis canadensis L.) on acetaminophen-induced hepatotoxicity through inhibition of CYP2E1 in rats