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While this reaction was traditionally viewed as a minor nicotinamide clearance pathway, research has revealed that NNMT activity has far-reaching consequences for cellular metabolism through multiple interconnected mechanisms

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The recent identification of hybrid ketoacid dehydrogenase complexes between the E1 subunit of OADHc (DHTKD1) and the OGDHc 40 indicates that more complex crosstalk exists between ketoacid dehydrogenases, and we speculate that these hybrid complexes may be more susceptible to acyl-lipoyl adduct formation

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To the best of our knowledge, this is the first study to demonstrate the application of in vivo genome editing for treatment of diseases not associated with specific genetic lesions or aberrations