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Kaplan A, Zelicha H, Yaskolka Meir A, Rinott E, Tsaban G, Levakov G, Prager O, Salti M, Yovell Y, Ofer J, Huhn S, Beyer F, Witte V, Villringer A, Meiran N, Emesh BT, Kovacs P, von Bergen M, Ceglarek U, Blher M, Stumvoll M, Hu FB, Stampfer MJ, Friedman A, Shelef I, Avidan G, Shai I (2022) The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: the Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT PLUS)

doi: 10.1016/0272-6386(95)90439-5

A., & Hadwan, M

While many of the key regulators of this pathway remain largely unknown, recent studies have identified glutathione peroxidases, particularly glutathione peroxidase 4 (GPX4), as antioxidant enzymes that can prevent lipid peroxidation using reduced glutathione (GSH) as a co-factor 9,10

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