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GLUT9 is a high-capacity electrogenic transporter that significantly activates membrane depolarization (uptake of extracellular [K + -Cl] in the medium), with a specific ability to transport uric acid unidirectionally through a voltage-dependent manner, seemingly influenced by extracellular Cl-concentration but independent of Na + transmembrane gradients [78]

That is a net treatment effect of approximately 5.4%

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doi: 10.1096/fj.09-132043

The geometric mean cost for CPT code 78431 is approximately $2,200