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The molecular stability of lipid-tailed GLP-1RAs, such as liraglutide and semaglutide, allows them to achieve active concentrations of 180350 pmol/L, while non-acylated agents like exenatide yield slightly lower levels (~ 50 pmol/L)

PMID 8110735

In order to elucidate in vivo mechanism of aldehyde-mediated tissue injury in ALDH2*2 carriers, here we investigate the pathology of Aldh2*2 knock-in (KI) mice with AA-induced acute exposure to acrolein, focusing on relationship between rapid systemic storm of reactive aldehydes and hepatocellular injury characterized by accumulation of aldehyde adducts

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