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Study 3 was a 56-week trial that enrolled 422 patients with obesity (BMI greater than or equal to 30 kg/m2) or with overweight (BMI 27-29.9 kg/m2) and at least one weight-related comorbid condition such as treated or untreated dyslipidemia or hypertension

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All of these negative effects were prevented in the polyphenol group (Hokayem 2013)

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Transglutaminase 2 crosslinks the glutathione S-transferase tag, impeding proteinprotein interactions of the fused protein

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