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Parkinsons disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled

Neuropsychopharmacology 29 , 17821789 (2004)

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Despite the intestinal barrier being designed to limit the translocation of luminal components, certain factors disrupt its integrity including genetic predisposition, gut microbiota dysbiosis and environmental factors such as those present in food and oral therapeutics (Fig