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[2] Systemically, angiogenic activity is a double-edged property in principle helpful for perfusing regenerating tissue, but something that any candidate with pro-angiogenic signaling must be evaluated against carefully in other contexts, including any setting where promoting blood-vessel growth would be undesirable

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N Engl J Med 375(4):311322 Marso SP, Bain SC, Consoli A, Eliaschewitz FG, Jodar E, Leiter LA et al (2016) Semaglutide and cardiovascular outcomes in patients with type 2 diabetes