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Patients were given a single tablet of B vitamins containing 2.5 milligrams of folic acid, 25 milligrams of vitamin B6 and one milligram of vitamin B12 per day for 36 months or a matching placebo

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Une revue systmatique de 18 tudes rvle que les effets sont optimiss avec des dosages levs (?2g par jour), une dure de supplmentation prolonge (8 12 semaines minimum) et une co-ingestion avec des glucides pour amliorer l'absorption