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The reaction is more pronounced under certain specific conditions

These include: oral (swallowed into the stomach) intravenous (injected into the vein) subcutaneous (injected into the fatty tissue just under the layer of skin) Intramuscular injections may sometimes be used instead of intravenous injections because some drugs are irritating to veins or because a suitable vein cannot be located

"The Brain Hepatocyte Growth Factor/c-Met Receptor System: A New Target for the Treatment of Alzheimer's Disease." Journal of Alzheimer's Disease

Protect from light

Eric Topol of Scripps Research Translational Institute, who has studied the issue