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DISCUSSION This is the first study to demonstrate that ARA 290 appears to be safe when administered repeatedly over a 4-wk period to sarcoidosis patients with symptoms of SFN

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Argireline acts as a competitive inhibitor of SNAP25, which prevents SNARE from facilitating synaptic vesicle Ca(2+)-dependent exocytosis for the release of neurotransmitters mediating muscle contractions such as acetylcholine [23]

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This suggests BPC-157 modulates the angiogenic response through pathway interactions rather than acting as a direct angiogenic factor