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Last but not least, GSH participates in non-enzymatic conjugation with some chemicals, for instance, it is hypothesized that glutathione reacts with n-acetyl-p-benzoquinone imine (NAPQI) -the cytochrome P450 reactive metabolite formed by toxic overdose of acetaminophen- to detoxify it.

10.3390/jcdd6030027 54 UpadhyayR

Taking a smaller dose every day is more effective than taking a large dose once a week

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These results indicated that the Pro198Leu polymorphism in GPx1 and the associated LOH are factors of significance in breast cancer development