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The study protocol and informed consent obtained from patients with CVD were approved by the Institutional Review Board of National Taiwan University Hospital (201712030RIND) and all participants in this study had signed a waiver of informed consent

16 h post-transfection, the medium was exchanged with DMEM complete medium, and 48 h after the start of the transfection, the viral supernatant was harvested, filtered (0.45 m), and stored at 80C

The average number of Halo-Rac1 molecules per EV, as determined by western blotting, was approximately 2.5 10 3 molecules (Supplementary Fig

All Benzyl Alcohol vials are independently third-party tested and HPLC-verified at 99% purity

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