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The third mechanism of calcitriols action could be indirect, via a stimulatory effect on parathyroid CaSR expression, as shown by Brown et al (70) and subsequently confirmed by Mendoza et al (71)

For example, the chemotherapeutic agent doxorubicin generates ROS as part of its mechanism of action, contributing to its cytotoxic effects

Piwowarczyk B, Tokarz K, Muszyska E, Makowski W, Jdrzejczyk R, Gajewski Z, Hanus- Fajerska E (2018) The acclimatization strategies of kidney vetch (Anthyllis vulneraria L.) to Pb toxicity

So, what can be done to address this emerging medication toxicity