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Recommendations for vitamin supplementation should be individualized and based on blood levels of folate, vitamin B6, and vitamin B12

Simultaneously, the opening of the mitochondrial permeabilization transition pore (mPTP) releases pro-apoptotic factors (such as Cyt-c), triggering endothelial cell death

Coskun and colleagues (Cell Metabolism, 2022) provided the foundational characterisation, demonstrating that balanced engagement of all three receptors produces metabolic effects not achievable through dual or single-receptor pharmacology alone

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doi: 10.1016/j.jaci.2011.01.068 91 SvendsenMTMllerSFeldmanSRAndersenKE