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Leptin increases circulating estrogen levels and acts within the hypothalamus to improve bone metabolism

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declares having received consulting honoraria from Amgen, Boehringer Ingelheim, Merck, Pfizer, Aegerion, Novartis, Sanofi, Takeda, Novo Nordisk and Bayer, and research grants from British Heart Foundation, MRC (UK), NIHR, PHE, MSD, Pfizer, Aegerion, Colgate and Roche

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Patients who titrate slowly over 20-24 weeks (versus the standard 12-16 weeks) report significantly fewer GI symptoms