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Commonly investigated in dermatology and biomaterials research, AHK-Cu is used in models focused on collagen/elastin dynamics, inflammatory signaling balance, and oxidative-stress response

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267,268 Under oxidative stress conditions, Nrf2 dissociates from Keap1 following thiol modifications of its cysteine residues, preventing Nrf2 ubiquitination and proteasomal degradation

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