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Excessive copper intake has also been linked to alterations in the gut microbiota, which in turn can lead to a range of conditions such as polycystic ovary syndrome (61)

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A statistically significant increase in thyroid C-cell adenomas was observed in males and females at all dose levels, and a statistically significant increase in thyroid C-cell carcinomas was observed in males at 0.01 mg/kg/day, at clinically relevant exposures