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We do not know whether tirzepatide specifically, with its dual GIP and GLP-1 action, offers migraine benefits beyond what pure GLP-1 agonists provide

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The main outcomes were the incidence of diabetes and cardiovascular disease, where the latter included hospitalized myocardial infarction, stroke, or heart failure

Oral melanotic macules An oral melanotic macule, by conventional definition is a focal, well-defined, uniformly coloured oral mucosal hyperpigmentation, less than 1 cm in diameter, of unknown aetiology

Semaglutide works by targeting the GLP-1 pathway alone