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However, in case of the ASCT2, studies showed that cysteine is actually a competitive inhibitor and not a substrate for ASCT2 ( Figure 1 via Multidrug Resistance Protein 1 exporter (MRP1), is cleaved extracellularly by -Glutamyl transferase (GGT) forming -Glutamyl-X substrate and Cysteinyl-Glycine

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Finally, we demonstrated that long-term HDF consumption downregulated the expression of hepatic Grx, the enzyme catalyzing the de-glutathionylation reaction 32

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