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Smaller dose-finding work (Falutz et al., PMID 22298602 review) established that lower doses produced proportionally lower visceral-fat reduction and lower IGF-1 elevation

The long-term safety profile remains a question mark, and pharmacy availability is years away

A previous study from our laboratory established that the GLP-1R function in pancreatic beta cells is also modulated by cholesterol

This symptom overlap is why medical supervision is essential when combining GLP-1 therapy with an IBS diagnosis

As in the previous recommendations by the ADA and EASD (73, 74), life-style intervention (with patient education and motivation, increase of physical activity, and healthy eating) is still in the beginning and center of therapy, followed by pharmacological therapy with metformin (7074)