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High non-ceruloplasmin-bound copper can increase oxidative stress, while low zinc may impair copper regulation and SOD1/SOD3 structure

Quantitative Real-Time PCR A total RNA extraction kit (Vazyme, Nanjing, China) was used to collect total RNA from TPC-1 and KTC-1 cells

More recently, safety and limited but significant efficacy of Ebselen has been shown in humans (Kil et al., 2017), supporting interventions on enzymatic activities in glutathione metabolic routes as a promising therapeutic avenue

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Li M, Meng Z, Yu S et al (2022a) Baicalein ameliorates cerebral ischemia-reperfusion injury by inhibiting ferroptosis via regulating GPX4/ACSL4/ACSL3 axis