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L.BousquetJ.AgacheI.AgarwalA.BachertC.Bosnic-AnticevichS.et al (2017)

For bile to stay fluid and prevent gallstone formation, there must be a proper balance between cholesterol and phosphatidylcholine, ideally at a 1:10 ratio

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DAC stands for Drug Affinity Complex , a molecular structure added to a peptide to prolong its half-life

At 40 weeks, all three doses (3 mg, 12 mg, 36 mg) of orforglipron achieved the primary endpoint of superior A1C reduction compared to placebo , lowering A1C by 1.3% to 1.6% from a baseline of 8.0% , with improvements seen as early as 4 weeks