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Moreover, the decreased thrombomodulin-dependent activation of protein C observed in hyperhomocysteinemic primates suggests that a moderate increase in circulating homocysteine alters endothelial antithrombotic properties (Lentz et al, 1996)

Adil A, Godwin M

A study published in the Journal of Clinical Endocrinology and Metabolism found that women deficient in Vitamin D are half as likely to conceive as compared to women without Vitamin D deficiency

10.1016/j.gendis.2023.04.022 11 HirschhornT.StockwellB

An important part of the answer, it appears, is infection and inflammation (see section The Main Problem Is Pathogens, Not Amyloids)